TULP3

Entrez Summary: N/A
UniProt Summary: Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT- A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. {ECO:0000269|PubMed:11375483, ECO:0000269|PubMed:20889716}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Vitamin-D3 40μM R08 exp536	1.74
VER-155008 3.9μM R06 exp301	2.13

bronchus morphogenesis
9+0 non-motile cilium
intraciliary transport particle A binding
negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
embryonic neurocranium morphogenesis
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
bronchus development
ganglion development
dorsal/ventral neural tube patterning
spinal cord dorsal/ventral patterning
spinal cord patterning
negative regulation of embryonic development
negative regulation of smoothened signaling pathway
neural tube patterning
ciliary base
embryonic camera-type eye development
embryonic cranial skeleton morphogenesis
protein localization to cilium
embryonic digit morphogenesis
cranial skeletal system development
G protein-coupled receptor binding
smoothened signaling pathway
phosphatidylinositol-4,5-bisphosphate binding
regulation of smoothened signaling pathway
dorsal/ventral pattern formation
phosphatidylinositol binding
neural tube closure
tube closure
embryonic skeletal system morphogenesis
primary neural tube formation
axoneme
neural tube formation
spinal cord development
embryonic epithelial tube formation
embryonic limb morphogenesis
embryonic appendage morphogenesis
embryonic skeletal system development
regulation of embryonic development