TWSG1

Gene Information

Official Symbol: TWSG1
Official Name: twisted gastrulation BMP signaling modulator 1
Aliases and Previous Symbols: N/A
Entrez ID: 57045
UniProt: Q9GZX9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15687
Expression level (log2 read counts): 4.37

Expression Distribution

negative regulation of CD4-positive, alpha-beta T cell proliferation
negative regulation of alpha-beta T cell proliferation
regulation of CD4-positive, alpha-beta T cell proliferation
transforming growth factor beta binding
salivary gland morphogenesis
negative regulation of CD4-positive, alpha-beta T cell activation
regulation of alpha-beta T cell proliferation
positive regulation of BMP signaling pathway
salivary gland development
negative regulation of alpha-beta T cell activation
exocrine system development
negative regulation of osteoblast differentiation
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of BMP signaling pathway
negative regulation of T cell proliferation
regulation of CD4-positive, alpha-beta T cell activation
regulation of pathway-restricted SMAD protein phosphorylation
mesoderm formation
mesoderm morphogenesis
negative regulation of ossification
negative regulation of mononuclear cell proliferation
negative regulation of lymphocyte proliferation
negative regulation of leukocyte proliferation
regulation of BMP signaling pathway
BMP signaling pathway
regulation of alpha-beta T cell activation
gland morphogenesis
transforming growth factor beta receptor signaling pathway
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
cellular response to BMP stimulus
response to BMP
negative regulation of T cell activation
formation of primary germ layer
regulation of osteoblast differentiation
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of leukocyte cell-cell adhesion
mesoderm development
negative regulation of lymphocyte activation
negative regulation of cellular response to growth factor stimulus
cellular response to transforming growth factor beta stimulus