TXNDC12

Entrez Summary: N/A
UniProt Summary: Possesses significant protein thiol-disulfide oxidase activity. {ECO:0000269|PubMed:12761212}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein-disulfide reductase (glutathione) activity
peptide disulfide oxidoreductase activity
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of response to endoplasmic reticulum stress
cell redox homeostasis
regulation of response to endoplasmic reticulum stress
negative regulation of intrinsic apoptotic signaling pathway
regulation of intrinsic apoptotic signaling pathway
negative regulation of apoptotic signaling pathway
endoplasmic reticulum lumen
regulation of apoptotic signaling pathway
negative regulation of intracellular signal transduction
regulation of cellular response to stress
negative regulation of apoptotic process
cellular homeostasis
negative regulation of programmed cell death
oxidation-reduction process
negative regulation of cell death
endoplasmic reticulum
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
regulation of response to stress
regulation of apoptotic process
regulation of programmed cell death
negative regulation of response to stimulus
homeostatic process
regulation of cell death
regulation of intracellular signal transduction