UBE2B [The Human Chemical-Genetic Interaction Map Project]

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======= UBE2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2B
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7320|7320]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63146|P63146]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179095|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys- 164'. May be involved in neurite outgrowth. {ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289, ECO:0000269|PubMed:1717990, ECO:0000269|PubMed:20061386}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of reciprocal meiotic recombination|
|positive regulation of reciprocal meiotic recombination|
|negative regulation of histone phosphorylation|
|maintenance of chromatin silencing|
|positive regulation of meiosis I|
|HULC complex|
|chiasma assembly|
|regulation of meiosis I|
|meiotic telomere clustering|
|sperm axoneme assembly|
|chromosome localization to nuclear envelope involved in homologous chromosome segregation|
|regulation of histone phosphorylation|
|telomere localization|
|XY body|
|positive regulation of meiotic nuclear division|
|negative regulation of cAMP-mediated signaling|
|histone H2A ubiquitination|
|synaptonemal complex organization|
|positive regulation of meiotic cell cycle|
|replication fork|
|histone lysine demethylation|
|histone demethylation|
|protein K11-linked ubiquitination|
|regulation of meiotic nuclear division|
|protein dealkylation|
|protein demethylation|
|protein K63-linked ubiquitination|
|DNA damage response, detection of DNA damage|
|positive regulation of DNA recombination|
|histone ubiquitination|
|ubiquitin conjugating enzyme activity|
|negative regulation of histone modification|
|synapsis|
|regulation of meiotic cell cycle|
|regulation of cAMP-mediated signaling|
|reciprocal meiotic recombination|
|homologous recombination|
|protein K48-linked ubiquitination|
|postreplication repair|
|homologous chromosome segregation|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|protein monoubiquitination|
|negative regulation of chromatin organization|
|axoneme assembly|
|demethylation|
|chromosome organization involved in meiotic cell cycle|
|protein autoubiquitination|
|positive regulation of nuclear division|
|chromatin organization involved in regulation of transcription|
|flagellated sperm motility|
|sperm motility|
|establishment of chromosome localization|
|chromosome localization|
|positive regulation of reproductive process|
|negative regulation of gene expression, epigenetic|
|meiotic chromosome segregation|
|microtubule bundle formation|
|cilium-dependent cell motility|
|cilium or flagellum-dependent cell motility|
|regulation of DNA recombination|
|meiosis I|
|meiosis I cell cycle process|
|chromatin|
|negative regulation of chromosome organization|
|response to UV|
|positive regulation of canonical Wnt signaling pathway|
|regulation of histone modification|
|spermatid development|
|meiotic nuclear division|
|gene silencing|
|spermatid differentiation|
|regulation of reproductive process|
|meiotic cell cycle process|
|positive regulation of Wnt signaling pathway|
|protein stabilization|
|regulation of chromatin organization|
|regulation of nuclear division|
|positive regulation of DNA metabolic process|
|nuclear chromosome segregation|
|DNA recombination|
|meiotic cell cycle|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|ubiquitin-protein transferase activity|
|germ cell development|
|chromosome segregation|
|regulation of canonical Wnt signaling pathway|
|nuclear division|
|positive regulation of cell cycle process|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|protein polyubiquitination|
|response to light stimulus|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|cilium assembly|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|cellular process involved in reproduction in multicellular organism|
|regulation of DNA metabolic process|
|regulation of Wnt signaling pathway|
|establishment of organelle localization|
|histone modification|
|cilium organization|
|negative regulation of organelle organization|
|covalent chromatin modification|
|in utero embryonic development|
|positive regulation of cell cycle|
|negative regulation of protein phosphorylation|
|response to radiation|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|microtubule cytoskeleton organization|
|negative regulation of intracellular signal transduction|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|spermatogenesis|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|microtubule-based process|
|protein catabolic process|
|protein ubiquitination|
|detection of stimulus|
|gamete generation|
|chromatin organization|
|negative regulation of cellular component organization|
|DNA metabolic process|
|regulation of cell cycle process|
|organelle assembly|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of apoptotic process|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|embryo development|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|negative regulation of cell death|
|cell cycle process|
|response to drug|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15004
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2B Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>