UBE2B

Gene Information

Official Symbol: UBE2B
Official Name: ubiquitin conjugating enzyme E2 B
Aliases and Previous Symbols: N/A
Entrez ID: 7320
UniProt: P63146
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008].
UniProt Summary: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys- 164'. May be involved in neurite outgrowth. {ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:17130289, ECO:0000269|PubMed:1717990, ECO:0000269|PubMed:20061386}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15004
Expression level (log2 read counts): 5.05

Expression Distribution

regulation of reciprocal meiotic recombination
positive regulation of reciprocal meiotic recombination
negative regulation of histone phosphorylation
maintenance of chromatin silencing
positive regulation of meiosis I
HULC complex
chiasma assembly
regulation of meiosis I
meiotic telomere clustering
sperm axoneme assembly
chromosome localization to nuclear envelope involved in homologous chromosome segregation
regulation of histone phosphorylation
telomere localization
XY body
positive regulation of meiotic nuclear division
negative regulation of cAMP-mediated signaling
histone H2A ubiquitination
synaptonemal complex organization
positive regulation of meiotic cell cycle
replication fork
histone lysine demethylation
histone demethylation
protein K11-linked ubiquitination
regulation of meiotic nuclear division
protein dealkylation
protein demethylation
protein K63-linked ubiquitination
DNA damage response, detection of DNA damage
positive regulation of DNA recombination
histone ubiquitination
ubiquitin conjugating enzyme activity
negative regulation of histone modification
synapsis
regulation of meiotic cell cycle
regulation of cAMP-mediated signaling
reciprocal meiotic recombination
homologous recombination
protein K48-linked ubiquitination
postreplication repair
homologous chromosome segregation