UBL5 [The Human Chemical-Genetic Interaction Map Project]

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======= UBL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBL5
  * **<color #00a2e8>Official Name</color>**: ubiquitin like 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=59286|59286]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZL1|Q9BZL1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606849|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ubiquitin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein tag|
|positive regulation of protein targeting to mitochondrion|
|regulation of protein targeting to mitochondrion|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|positive regulation of mitochondrion organization|
|positive regulation of intracellular protein transport|
|regulation of mitochondrion organization|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|RNA splicing|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|mRNA processing|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|mRNA metabolic process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|RNA processing|
|regulation of cellular localization|
|positive regulation of transport|
|regulation of protein localization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|RNA metabolic process|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.79|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nup43|NUP43]]|0.459|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.449|
|[[:human genes:r:rad21|RAD21]]|0.442|
|[[:human genes:d:dtl|DTL]]|0.421|
|[[:human genes:p:plk1|PLK1]]|0.421|
|[[:human genes:h:hap1|HAP1]]|0.418|
|[[:human genes:v:vasn|VASN]]|0.416|
|[[:human genes:i:ik|IK]]|0.415|
|[[:human genes:t:tceb3c|TCEB3C]]|0.415|
|[[:human genes:c:cbwd5|CBWD5]]|0.415|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.414|
|[[:human genes:z:zfand5|ZFAND5]]|0.412|
|[[:human genes:h:hivep3|HIVEP3]]|0.411|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.411|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.41|
|[[:human genes:p:pola2|POLA2]]|0.409|
|[[:human genes:r:rfpl3|RFPL3]]|0.408|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.406|
|[[:human genes:c:cdc45|CDC45]]|0.406|
|[[:human genes:c:cbwd3|CBWD3]]|0.405|
|[[:human genes:u:utp20|UTP20]]|0.401|
|[[:human genes:s:slc4a1|SLC4A1]]|0.4|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.4|
|[[:human genes:r:rad51|RAD51]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 731/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|19/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 297
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBL5 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>