UBR4 [The Human Chemical-Genetic Interaction Map Project]

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======= UBR4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBR4
  * **<color #00a2e8>Official Name</color>**: ubiquitin protein ligase E3 component n-recognin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23352|23352]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T4S7|Q5T4S7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBR4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBR4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609890|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ficolin-1-rich granule membrane|
|tertiary granule membrane|
|specific granule membrane|
|calmodulin binding|
|ubiquitin-protein transferase activity|
|neutrophil degranulation|
|centrosome|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|myeloid leukocyte activation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|protein catabolic process|
|protein ubiquitination|
|viral process|
|regulated exocytosis|
|leukocyte mediated immunity|
|protein modification by small protein conjugation|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|zinc ion binding|
|cellular macromolecule catabolic process|
|leukocyte activation|
|protein modification by small protein conjugation or removal|
|secretion by cell|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|secretion|
|proteolysis|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.13|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.07|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.86|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.77|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.78|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.9|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.97|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.99|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.1|
|[[:results:exp539|42°C R08 exp539]]|2.44|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|3.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kcmf1|KCMF1]]|0.517|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 557/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|15/28|
|bone|16/26|
|breast|32/33|
|central nervous system|41/56|
|cervix|2/4|
|colorectal|14/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|13/21|
|liver|12/20|
|lung|63/75|
|lymphocyte|10/16|
|ovary|22/26|
|pancreas|15/24|
|peripheral nervous system|6/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|19/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|22/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1574
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBR4 Expression in NALM6 Cells: 8.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>