UBXN6 [The Human Chemical-Genetic Interaction Map Project]

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======= UBXN6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBXN6
  * **<color #00a2e8>Official Name</color>**: UBX domain protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80700|80700]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZV1|Q9BZV1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBXN6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBXN6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611946|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). {ECO:0000269|PubMed:19275885, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26475856, ECO:0000269|PubMed:27753622}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBX|
|PUB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endosome to lysosome transport via multivesicular body sorting pathway|
|endosome transport via multivesicular body sorting pathway|
|multivesicular body sorting pathway|
|endosome to lysosome transport|
|extrinsic component of membrane|
|ERAD pathway|
|lysosomal transport|
|late endosome membrane|
|vacuolar transport|
|early endosome membrane|
|microtubule organizing center|
|macroautophagy|
|endosomal transport|
|response to endoplasmic reticulum stress|
|process utilizing autophagic mechanism|
|autophagy|
|lysosomal membrane|
|proteasomal protein catabolic process|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|cellular protein catabolic process|
|protein catabolic process|
|cellular macromolecule catabolic process|
|response to organonitrogen compound|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|proteolysis|
|intracellular transport|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.72|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10281
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBXN6 Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>