UBXN6

Entrez Summary: N/A
UniProt Summary: May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). {ECO:0000269|PubMed:19275885, ECO:0000269|PubMed:21822278, ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26475856, ECO:0000269|PubMed:27753622}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
I-BRD9 4μM R07 exp365	1.72
Rapamycin 10μM R00 exp30	1.8

UBX
PUB

endosome to lysosome transport via multivesicular body sorting pathway
endosome transport via multivesicular body sorting pathway
multivesicular body sorting pathway
endosome to lysosome transport
extrinsic component of membrane
ERAD pathway
lysosomal transport
late endosome membrane
vacuolar transport
early endosome membrane
microtubule organizing center
macroautophagy
endosomal transport
response to endoplasmic reticulum stress
process utilizing autophagic mechanism
autophagy
lysosomal membrane
proteasomal protein catabolic process
proteolysis involved in cellular protein catabolic process
protein-containing complex
cellular protein catabolic process
protein catabolic process
cellular macromolecule catabolic process
response to organonitrogen compound
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
proteolysis
intracellular transport
cellular response to stress
organic substance catabolic process
cellular catabolic process
establishment of localization in cell
vesicle-mediated transport