ULK4

Entrez Summary: This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016].
UniProt Summary: May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility. {ECO:0000269|PubMed:24284070}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase Tyr
Pkinase

regulation of protein kinase C signaling
regulation of p38MAPK cascade
regulation of neuron migration
regulation of JNK cascade
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
protein serine/threonine kinase activity
microtubule cytoskeleton organization
regulation of neuron projection development
regulation of neuron differentiation
microtubule-based process
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of cellular response to stress
regulation of MAPK cascade
regulation of neurogenesis
regulation of cell migration
regulation of cell motility
regulation of nervous system development
regulation of cell development
protein phosphorylation
regulation of locomotion
regulation of cellular component movement
cytoskeleton organization
phosphorylation
regulation of protein phosphorylation
regulation of response to stress
ATP binding
generation of neurons
regulation of phosphorylation
neurogenesis
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of cell differentiation
regulation of intracellular signal transduction
regulation of protein modification process