USP50 [The Human Chemical-Genetic Interaction Map Project]

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======= USP50 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP50
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 50
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=373509|373509]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q70EL3|Q70EL3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP50&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP50|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620563|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has no peptidase activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-like protein-specific protease activity|
|positive regulation of interleukin-18 production|
|positive regulation of NLRP3 inflammasome complex assembly|
|regulation of interleukin-18 production|
|extrinsic component of endosome membrane|
|positive regulation of protein homooligomerization|
|regulation of NLRP3 inflammasome complex assembly|
|regulation of protein homooligomerization|
|positive regulation of protein oligomerization|
|extrinsic component of plasma membrane|
|protein K63-linked deubiquitination|
|protein K48-linked deubiquitination|
|positive regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 secretion|
|regulation of protein oligomerization|
|regulation of interleukin-1 beta secretion|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-1 secretion|
|thiol-dependent ubiquitinyl hydrolase activity|
|positive regulation of interleukin-1 production|
|endosome organization|
|regulation of interleukin-1 beta production|
|regulation of interleukin-1 production|
|thiol-dependent ubiquitin-specific protease activity|
|positive regulation of cytokine secretion|
|dendritic spine|
|positive regulation of cysteine-type endopeptidase activity|
|midbody|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|regulation of cytokine secretion|
|regulation of cysteine-type endopeptidase activity|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|postsynaptic density|
|positive regulation of protein secretion|
|protein deubiquitination|
|positive regulation of peptide secretion|
|protein modification by small protein removal|
|vesicle organization|
|small GTPase mediated signal transduction|
|positive regulation of proteolysis|
|positive regulation of secretion by cell|
|regulation of endopeptidase activity|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of secretion|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|positive regulation of cellular component biogenesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of secretion|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|positive regulation of cellular protein metabolic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.89|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.84|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.72|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.73|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.75|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15711
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP50 Expression in NALM6 Cells: -0.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>