USP50
Gene Information
- Official Symbol: USP50
- Official Name: ubiquitin specific peptidase 50
- Aliases and Previous Symbols: N/A
- Entrez ID: 373509
- UniProt: Q70EL3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Has no peptidase activity.
Pfam Domains GO Terms
Pfam Domains
| UCH |
GO Terms
| ubiquitin-like protein-specific protease activity |
| positive regulation of interleukin-18 production |
| positive regulation of NLRP3 inflammasome complex assembly |
| regulation of interleukin-18 production |
| extrinsic component of endosome membrane |
| positive regulation of protein homooligomerization |
| regulation of NLRP3 inflammasome complex assembly |
| regulation of protein homooligomerization |
| positive regulation of protein oligomerization |
| extrinsic component of plasma membrane |
| protein K63-linked deubiquitination |
| protein K48-linked deubiquitination |
| positive regulation of interleukin-1 beta secretion |
| positive regulation of interleukin-1 secretion |
| regulation of protein oligomerization |
| regulation of interleukin-1 beta secretion |
| positive regulation of interleukin-1 beta production |
| regulation of interleukin-1 secretion |
| thiol-dependent ubiquitinyl hydrolase activity |
| positive regulation of interleukin-1 production |
| endosome organization |
| regulation of interleukin-1 beta production |
| regulation of interleukin-1 production |
| thiol-dependent ubiquitin-specific protease activity |
| positive regulation of cytokine secretion |
| dendritic spine |
| positive regulation of cysteine-type endopeptidase activity |
| midbody |
| positive regulation of endopeptidase activity |
| positive regulation of peptidase activity |
| regulation of cytokine secretion |
| regulation of cysteine-type endopeptidase activity |
| Ras protein signal transduction |
| positive regulation of protein complex assembly |
| postsynaptic density |
| positive regulation of protein secretion |
| protein deubiquitination |
| positive regulation of peptide secretion |
| protein modification by small protein removal |
| vesicle organization |
| small GTPase mediated signal transduction |
| positive regulation of proteolysis |
| positive regulation of secretion by cell |
| regulation of endopeptidase activity |
| endomembrane system organization |
| positive regulation of protein transport |
| positive regulation of secretion |
| regulation of peptidase activity |
| positive regulation of cytokine production |
| regulation of protein complex assembly |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of peptide secretion |
| positive regulation of cellular component biogenesis |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| regulation of cytokine production |
| regulation of protein transport |
| regulation of proteolysis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| positive regulation of hydrolase activity |
| regulation of secretion |
| cellular macromolecule catabolic process |
| regulation of cellular component biogenesis |
| protein modification by small protein conjugation or removal |
| positive regulation of transport |
| regulation of protein localization |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| positive regulation of cellular component organization |
| proteolysis |
| regulation of hydrolase activity |
| positive regulation of catalytic activity |
| positive regulation of cellular protein metabolic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM0011500 5μM R05 exp245 | -1.89 |
| S-trityl-L-cysteine 0.5μM R05 exp243 | -1.84 |
| Rifampicin 1μM R00 exp31 | -1.72 |
| Bafilomycin-A1 0.009μM R08 exp454 | 1.73 |
| BI-D1870 3.15μM R02 exp66 | 1.75 |
| FTY720 3μM R08 exp483 | 1.88 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15711
- Expression level (log2 read counts): -0.13
Expression Distribution
USP50 Expression in NALM6 Cells: -0.13
