VAMP2
Gene Information
- Official Symbol: VAMP2
- Official Name: vesicle associated membrane protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6844
- UniProt: P63027
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63045}.
Pfam Domains GO Terms
Pfam Domains
| Synaptobrevin |
GO Terms
| synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex |
| eosinophil degranulation |
| eosinophil activation |
| clathrin-sculpted glutamate transport vesicle membrane |
| eosinophil activation involved in immune response |
| mucus secretion |
| synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex |
| eosinophil mediated immunity |
| synaptobrevin 2-SNAP-25-syntaxin-1a complex |
| clathrin-sculpted monoamine transport vesicle membrane |
| natural killer cell degranulation |
| regulation of histamine secretion by mast cell |
| clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane |
| zymogen granule membrane |
| regulation of delayed rectifier potassium channel activity |
| neuron projection terminus |
| secretion by tissue |
| natural killer cell activation involved in immune response |
| natural killer cell mediated cytotoxicity |
| syntaxin-1 binding |
| natural killer cell mediated immunity |
| glutamate secretion |
| Golgi to plasma membrane protein transport |
| regulation of mast cell degranulation |
| regulation of mast cell activation involved in immune response |
| calcium-ion regulated exocytosis |
| leukocyte mediated cytotoxicity |
| regulation of mast cell activation |
| acidic amino acid transport |
| long-term synaptic potentiation |
| SNARE complex |
| regulation of leukocyte degranulation |
| establishment of protein localization to plasma membrane |
| clathrin-coated vesicle membrane |
| syntaxin binding |
| regulation of potassium ion transmembrane transporter activity |
| protein self-association |
| natural killer cell activation |
| clathrin-coated vesicle |
| regulation of myeloid leukocyte mediated immunity |
| Golgi to plasma membrane transport |
| calcium-dependent protein binding |
| synaptic vesicle exocytosis |
| SNARE binding |
| synaptic vesicle membrane |
| carbohydrate derivative transport |
| body fluid secretion |
| dicarboxylic acid transport |
| acid secretion |
| regulation of potassium ion transmembrane transport |
| voltage-gated potassium channel complex |
| secretory granule |
| cell killing |
| vesicle-mediated transport to the plasma membrane |
| regulation of potassium ion transport |
| secretory granule membrane |
| signal release from synapse |
| neurotransmitter secretion |
| post-Golgi vesicle-mediated transport |
| phospholipid binding |
| lymphocyte activation involved in immune response |
| synaptic vesicle cycle |
| amino acid transport |
| synaptic vesicle |
| vesicle-mediated transport in synapse |
| membrane fusion |
| response to glucose |
| vesicle |
| regulation of neurotransmitter transport |
| response to hexose |
| response to monosaccharide |
| positive regulation of synaptic transmission |
| positive regulation of intracellular protein transport |
| cellular response to insulin stimulus |
| regulation of regulated secretory pathway |
| signal release |
| trans-Golgi network |
| regulation of cation channel activity |
| response to carbohydrate |
| neurotransmitter transport |
| protein localization to plasma membrane |
| regulation of synaptic plasticity |
| calmodulin binding |
| regulation of leukocyte mediated immunity |
| positive regulation of intracellular transport |
| positive regulation of immune effector process |
| regulation of exocytosis |
| response to insulin |
| protein localization to cell periphery |
| regulation of intracellular protein transport |
| cytoplasmic vesicle |
| regulation of ion transmembrane transporter activity |
| establishment of protein localization to membrane |
| regulation of transmembrane transporter activity |
| lymphocyte mediated immunity |
| cellular response to peptide hormone stimulus |
| regulation of hormone secretion |
| synapse |
| regulation of transporter activity |
| carboxylic acid transport |
| organic acid transport |
| neuron projection |
| positive regulation of cellular protein localization |
| cellular response to peptide |
| regulation of cation transmembrane transport |
| regulation of inflammatory response |
| regulation of intracellular transport |
| regulation of neurotransmitter levels |
| Golgi vesicle transport |
| lymphocyte activation |
| regulation of metal ion transport |
| response to peptide hormone |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| positive regulation of protein transport |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| organic anion transport |
| positive regulation of establishment of protein localization |
| synaptic signaling |
| regulation of immune effector process |
| response to peptide |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| regulation of body fluid levels |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| regulation of hormone levels |
| regulation of cellular protein localization |
| cell junction |
| regulation of vesicle-mediated transport |
| regulation of transmembrane transport |
| anion transport |
| myeloid leukocyte activation |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| cellular response to hormone stimulus |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| cellular response to nitrogen compound |
| intracellular membrane-bounded organelle |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| regulated exocytosis |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| innate immune response |
| leukocyte mediated immunity |
| exocytosis |
| regulation of secretion |
| membrane organization |
| response to hormone |
| regulation of cellular localization |
| leukocyte activation |
| defense response to other organism |
| positive regulation of transport |
| response to organonitrogen compound |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| cellular response to oxygen-containing compound |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| regulation of response to external stimulus |
| cell-cell signaling |
| secretion |
| regulation of immune response |
| positive regulation of immune system process |
| cellular response to endogenous stimulus |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| ion transport |
| integral component of plasma membrane |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| peptide transport |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of immune system process |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Vemurafenib 6.6μM R08 exp434 | -1.93 |
| Salinomycin 3.5μM R08 exp521 | 1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8869
- Expression level (log2 read counts): 5.26
Expression Distribution
VAMP2 Expression in NALM6 Cells: 5.26
