VAMP4

Entrez Summary: N/A
UniProt Summary: Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UM131593 0.2μM R03 exp106	2.06
UMK57 0.6μM R03 exp107	2.23

synaptic vesicle to endosome fusion
synaptic vesicle endosomal processing
SNARE complex assembly
Golgi ribbon formation
regulation of synaptic vesicle endocytosis
regulation of synaptic vesicle recycling
integral component of synaptic vesicle membrane
Golgi to plasma membrane protein transport
establishment of protein localization to plasma membrane
clathrin-coated vesicle membrane
Golgi to plasma membrane transport
vesicle fusion
organelle membrane fusion
transport vesicle
trans-Golgi network membrane
vesicle-mediated transport to the plasma membrane
organelle fusion
post-Golgi vesicle-mediated transport
regulation of synaptic vesicle cycle
membrane fusion
Golgi organization
protein localization to plasma membrane
regulation of endocytosis
endoplasmic reticulum to Golgi vesicle-mediated transport
protein localization to cell periphery
endosomal transport
lysosome
establishment of protein localization to membrane
endosome
vesicle organization
Golgi vesicle transport
endomembrane system organization
microtubule cytoskeleton organization
protein localization to membrane
regulation of vesicle-mediated transport
cell surface
Golgi membrane
microtubule-based process
cellular protein-containing complex assembly
membrane organization