VANGL1

Entrez Summary: This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.09
5-Fluorouracil 2μM R00 exp1	-1.7

lateral plasma membrane
pigmentation
Wnt signaling pathway, planar cell polarity pathway
regulation of establishment of planar polarity
non-canonical Wnt signaling pathway
regulation of morphogenesis of an epithelium
regulation of animal organ morphogenesis
Wnt signaling pathway
cell-cell signaling by wnt
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of anatomical structure morphogenesis
cell-cell signaling