VASH1

Entrez Summary: N/A
UniProt Summary: Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity. {ECO:0000269|PubMed:15467828, ECO:0000269|PubMed:16488400, ECO:0000269|PubMed:16707096}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of lymphangiogenesis
regulation of lymphangiogenesis
labyrinthine layer blood vessel development
metallocarboxypeptidase activity
placenta blood vessel development
negative regulation of blood vessel endothelial cell migration
negative regulation of endothelial cell proliferation
regulation of cellular senescence
labyrinthine layer development
regulation of cell aging
negative regulation of endothelial cell migration
negative regulation of epithelial cell migration
apical part of cell
embryonic placenta development
regulation of blood vessel endothelial cell migration
negative regulation of angiogenesis
negative regulation of blood vessel morphogenesis
negative regulation of vasculature development
negative regulation of epithelial cell proliferation
regulation of endothelial cell proliferation
cell cycle arrest
placenta development
regulation of endothelial cell migration
regulation of epithelial cell migration
negative regulation of cell migration
actin binding
negative regulation of cell motility
regulation of angiogenesis
negative regulation of cellular component movement
angiogenesis
regulation of vasculature development
negative regulation of locomotion
regulation of epithelial cell proliferation
in utero embryonic development
blood vessel morphogenesis
reproductive structure development
reproductive system development
embryonic organ development
blood vessel development
vasculature development