VAV3 [The Human Chemical-Genetic Interaction Map Project]

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======= VAV3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VAV3
  * **<color #00a2e8>Official Name</color>**: vav guanine nucleotide exchange factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10451|10451]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKW4|Q9UKW4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VAV3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VAV3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605541|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CH|
|CAMSAP CH|
|SH3 2|
|SH2|
|C1 1|
|RhoGEF|
|PH|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Rac guanyl-nucleotide exchange factor activity|
|positive regulation of phosphatidylinositol 3-kinase activity|
|epidermal growth factor receptor binding|
|lamellipodium assembly|
|positive regulation of lipid kinase activity|
|positive regulation of B cell proliferation|
|lamellipodium organization|
|positive regulation of phospholipid metabolic process|
|regulation of phosphatidylinositol 3-kinase activity|
|SH3/SH2 adaptor activity|
|regulation of B cell proliferation|
|regulation of lipid kinase activity|
|vascular endothelial growth factor receptor signaling pathway|
|vesicle fusion|
|organelle membrane fusion|
|neutrophil chemotaxis|
|regulation of phospholipid metabolic process|
|ephrin receptor signaling pathway|
|granulocyte chemotaxis|
|neutrophil migration|
|integrin-mediated signaling pathway|
|organelle fusion|
|granulocyte migration|
|guanyl-nucleotide exchange factor activity|
|myeloid leukocyte migration|
|B cell receptor signaling pathway|
|positive regulation of lymphocyte proliferation|
|membrane fusion|
|positive regulation of mononuclear cell proliferation|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|positive regulation of leukocyte proliferation|
|platelet activation|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|positive regulation of lipid metabolic process|
|regulation of Rho protein signal transduction|
|leukocyte chemotaxis|
|positive regulation of B cell activation|
|Fc-epsilon receptor signaling pathway|
|regulation of cell size|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|cell chemotaxis|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|Fc receptor signaling pathway|
|regulation of Ras protein signal transduction|
|GTPase activator activity|
|blood coagulation|
|coagulation|
|antigen receptor-mediated signaling pathway|
|hemostasis|
|vesicle organization|
|angiogenesis|
|small GTPase mediated signal transduction|
|phagocytosis|
|regulation of small GTPase mediated signal transduction|
|positive regulation of lymphocyte activation|
|regulation of cellular component size|
|leukocyte migration|
|regulation of lipid metabolic process|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|blood vessel morphogenesis|
|positive regulation of GTPase activity|
|positive regulation of cell activation|
|plasma membrane bounded cell projection assembly|
|immune response-activating cell surface receptor signaling pathway|
|cell projection assembly|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|blood vessel development|
|regulation of body fluid levels|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|regulation of anatomical structure size|
|cardiovascular system development|
|chemotaxis|
|taxis|
|immune response-activating signal transduction|
|response to wounding|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of cell adhesion|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|tube development|
|membrane organization|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|cell migration|
|regulation of transferase activity|
|response to drug|
|positive regulation of phosphorylation|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|regulation of hydrolase activity|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.85|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.84|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15927
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VAV3 Expression in NALM6 Cells: 3.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>