VAV3
Gene Information
- Official Symbol: VAV3
- Official Name: vav guanine nucleotide exchange factor 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 10451
- UniProt: Q9UKW4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| CH |
| CAMSAP CH |
| SH3 2 |
| SH2 |
| C1 1 |
| RhoGEF |
| PH |
| SH3 1 |
GO Terms
| Rac guanyl-nucleotide exchange factor activity |
| positive regulation of phosphatidylinositol 3-kinase activity |
| epidermal growth factor receptor binding |
| lamellipodium assembly |
| positive regulation of lipid kinase activity |
| positive regulation of B cell proliferation |
| lamellipodium organization |
| positive regulation of phospholipid metabolic process |
| regulation of phosphatidylinositol 3-kinase activity |
| SH3/SH2 adaptor activity |
| regulation of B cell proliferation |
| regulation of lipid kinase activity |
| vascular endothelial growth factor receptor signaling pathway |
| vesicle fusion |
| organelle membrane fusion |
| neutrophil chemotaxis |
| regulation of phospholipid metabolic process |
| ephrin receptor signaling pathway |
| granulocyte chemotaxis |
| neutrophil migration |
| integrin-mediated signaling pathway |
| organelle fusion |
| granulocyte migration |
| guanyl-nucleotide exchange factor activity |
| myeloid leukocyte migration |
| B cell receptor signaling pathway |
| positive regulation of lymphocyte proliferation |
| membrane fusion |
| positive regulation of mononuclear cell proliferation |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| positive regulation of leukocyte proliferation |
| platelet activation |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| positive regulation of lipid metabolic process |
| regulation of Rho protein signal transduction |
| leukocyte chemotaxis |
| positive regulation of B cell activation |
| Fc-epsilon receptor signaling pathway |
| regulation of cell size |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| cell chemotaxis |
| regulation of mononuclear cell proliferation |
| regulation of leukocyte proliferation |
| Fc receptor signaling pathway |
| regulation of Ras protein signal transduction |
| GTPase activator activity |
| blood coagulation |
| coagulation |
| antigen receptor-mediated signaling pathway |
| hemostasis |
| vesicle organization |
| angiogenesis |
| small GTPase mediated signal transduction |
| phagocytosis |
| regulation of small GTPase mediated signal transduction |
| positive regulation of lymphocyte activation |
| regulation of cellular component size |
| leukocyte migration |
| regulation of lipid metabolic process |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| blood vessel morphogenesis |
| positive regulation of GTPase activity |
| positive regulation of cell activation |
| plasma membrane bounded cell projection assembly |
| immune response-activating cell surface receptor signaling pathway |
| cell projection assembly |
| wound healing |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of GTPase activity |
| blood vessel development |
| regulation of body fluid levels |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of lymphocyte activation |
| regulation of anatomical structure size |
| cardiovascular system development |
| chemotaxis |
| taxis |
| immune response-activating signal transduction |
| response to wounding |
| positive regulation of kinase activity |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| activation of immune response |
| regulation of cell activation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| tube morphogenesis |
| positive regulation of transferase activity |
| regulation of cell adhesion |
| positive regulation of cell death |
| enzyme linked receptor protein signaling pathway |
| positive regulation of hydrolase activity |
| cellular response to DNA damage stimulus |
| tube development |
| membrane organization |
| positive regulation of immune response |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| cell migration |
| regulation of transferase activity |
| response to drug |
| positive regulation of phosphorylation |
| cell activation |
| localization of cell |
| cell motility |
| immune effector process |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| cell projection organization |
| regulation of hydrolase activity |
| locomotion |
| G protein-coupled receptor signaling pathway |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| THZ531 0.225μM R08 exp444 | -1.85 |
| Artemisinin 50μM R08 exp450 | -1.84 |
| Rucaparib 6.5μM R08 exp520 | 1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15927
- Expression level (log2 read counts): 3.77
Expression Distribution
VAV3 Expression in NALM6 Cells: 3.77
