VN1R4 [The Human Chemical-Genetic Interaction Map Project]

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======= VN1R4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VN1R4
  * **<color #00a2e8>Official Name</color>**: vomeronasal 1 receptor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=317703|317703]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z5H5|Q7Z5H5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VN1R4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VN1R4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative pheromone receptor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|V1R|
|TAS2R|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pheromone receptor activity|
|pheromone binding|
|response to pheromone|
|G protein-coupled receptor signaling pathway|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.1|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.91|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.86|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.8|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.8|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.78|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.7|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.71|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.82|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.9|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.96|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.27|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8790
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VN1R4 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>