VPS13D [The Human Chemical-Genetic Interaction Map Project]

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======= VPS13D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS13D
  * **<color #00a2e8>Official Name</color>**: vacuolar protein sorting 13 homolog D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55187|55187]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5THJ4|Q5THJ4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS13D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS13D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608877|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBA|
|Chorein N|
|DUF1162|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein retention in Golgi apparatus|
|positive regulation of mitophagy|
|regulation of mitophagy|
|positive regulation of autophagy of mitochondrion|
|protein localization to Golgi apparatus|
|protein targeting to vacuole|
|regulation of autophagy of mitochondrion|
|establishment of protein localization to vacuole|
|protein localization to vacuole|
|extrinsic component of membrane|
|positive regulation of macroautophagy|
|maintenance of protein location in cell|
|cell|
|maintenance of location in cell|
|maintenance of protein location|
|positive regulation of mitochondrion organization|
|positive regulation of autophagy|
|vacuolar transport|
|maintenance of location|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|regulation of autophagy|
|protein targeting|
|positive regulation of cellular catabolic process|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|mitochondrion organization|
|positive regulation of organelle organization|
|protein localization to organelle|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|intracellular protein transport|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.67|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.89|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.72|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.93|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 440/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|16/28|
|blood|11/28|
|bone|13/26|
|breast|20/33|
|central nervous system|36/56|
|cervix|1/4|
|colorectal|13/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|14/21|
|liver|10/20|
|lung|47/75|
|lymphocyte|9/16|
|ovary|10/26|
|pancreas|16/24|
|peripheral nervous system|6/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|15/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 628
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS13D Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>