VWA9 [The Human Chemical-Genetic Interaction Map Project]

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======= VWA9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: INTS14
  * **<color #00a2e8>Official Name</color>**: integrator complex subunit 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81556|81556]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96SY0|Q96SY0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VWA9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VWA9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620878|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. {ECO:0000250|UniProtKB:Q9VPY0}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrator complex|
|snRNA 3-end processing|
|snRNA processing|
|snRNA metabolic process|
|ncRNA 3-end processing|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|ncRNA transcription|
|RNA 3-end processing|
|ncRNA processing|
|ncRNA metabolic process|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.81|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.72|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.82|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.95|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.99|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ints10|INTS10]]|0.661|
|[[:human genes:c:c7orf26|C7orf26]]|0.62|
|[[:human genes:a:asun|ASUN]]|0.602|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 46/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|2/26|
|breast|6/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|3/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1930
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VWA9 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>