VWA9

Entrez Summary: N/A
UniProt Summary: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. {ECO:0000250|UniProtKB:Q9VPY0}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 46/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	0/28
bone	2/26
breast	6/33
central nervous system	8/56
cervix	0/4
colorectal	3/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	3/20
lung	4/75
lymphocyte	1/16
ovary	1/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	2/29
uterus	0/5

Expression Distribution

integrator complex
snRNA 3-end processing
snRNA processing
snRNA metabolic process
ncRNA 3-end processing
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
RNA 3-end processing
ncRNA processing
ncRNA metabolic process
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression