VWC2

Entrez Summary: N/A
UniProt Summary: BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
HGC6.3	0.508
RUVBL2	0.446

interstitial matrix
AMPA glutamate receptor complex
negative regulation of BMP signaling pathway
basement membrane
regulation of BMP signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
positive regulation of cell-substrate adhesion
negative regulation of cellular response to growth factor stimulus
regulation of cell-substrate adhesion
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
synapse
regulation of cellular response to growth factor stimulus
positive regulation of neuron differentiation
positive regulation of cell adhesion
positive regulation of neurogenesis
positive regulation of nervous system development
positive regulation of cell development
cell junction
regulation of neuron differentiation
regulation of cell adhesion
molecular function
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
positive regulation of developmental process
generation of neurons
extracellular space
negative regulation of response to stimulus
neurogenesis
positive regulation of multicellular organismal process
regulation of cell differentiation