WDFY1

Gene Information
  • Official Symbol: WDFY1
  • Official Name: WD repeat and FYVE domain containing 1
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 57590
  • UniProt: Q8IWB7
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436). {ECO:0000269|PubMed:25736436}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 15650
  • Expression level (log2 read counts): 4.77

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1