WDR12 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR12
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55759|55759]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZL7|Q9GZL7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:16043514, ECO:0000269|PubMed:17353269}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|NLE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PeBoW complex|
|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of LSU-rRNA|
|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|preribosome, large subunit precursor|
|maturation of 5.8S rRNA|
|ribonucleoprotein complex binding|
|ribosomal large subunit biogenesis|
|Notch signaling pathway|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|cell population proliferation|
|nucleolus|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|-2.21|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.05|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 693/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|26/28|
|bone|25/26|
|breast|30/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|20/21|
|liver|17/20|
|lung|70/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|29/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 848
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR12 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>