WDR12

Entrez Summary: N/A
UniProt Summary: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:16043514, ECO:0000269|PubMed:17353269}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 693/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	25/28
blood	26/28
bone	25/26
breast	30/33
central nervous system	54/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	20/21
liver	17/20
lung	70/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	13/15
prostate	0/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	20/22
urinary tract	29/29
uterus	4/5

Expression Distribution

WD40
NLE

PeBoW complex
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of LSU-rRNA
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
preribosome, large subunit precursor
maturation of 5.8S rRNA
ribonucleoprotein complex binding
ribosomal large subunit biogenesis
Notch signaling pathway
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
cell population proliferation
nucleolus
RNA processing
RNA metabolic process
gene expression