WDR76

Entrez Summary: N/A
UniProt Summary: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Olaparib 4μM R08 exp512	-1.92
NFN1 0.1μM R01 exp49	-1.75

regulation of DNA damage checkpoint
site of DNA damage
heterochromatin
regulation of cell cycle checkpoint
regulation of response to DNA damage stimulus
enzyme binding
regulation of cellular response to stress
cellular response to DNA damage stimulus
regulation of cell cycle
DNA binding
regulation of response to stress
cellular response to stress