WDTC1 [The Human Chemical-Genetic Interaction Map Project]

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======= WDTC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDTC1
  * **<color #00a2e8>Official Name</color>**: WD and tetratricopeptide repeats 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23038|23038]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N5D0|Q8N5D0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDTC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDTC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619763|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16964240}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of fatty acid biosynthetic process|
|negative regulation of fatty acid metabolic process|
|enzyme inhibitor activity|
|regulation of fatty acid biosynthetic process|
|negative regulation of lipid biosynthetic process|
|multicellular organism growth|
|negative regulation of lipid metabolic process|
|regulation of fatty acid metabolic process|
|negative regulation of small molecule metabolic process|
|histone deacetylase binding|
|glucose metabolic process|
|histone binding|
|hexose metabolic process|
|cellular response to insulin stimulus|
|regulation of cellular ketone metabolic process|
|regulation of cell size|
|regulation of lipid biosynthetic process|
|monosaccharide metabolic process|
|response to insulin|
|cellular response to peptide hormone stimulus|
|cellular response to peptide|
|post-translational protein modification|
|in utero embryonic development|
|regulation of cellular component size|
|developmental growth|
|response to peptide hormone|
|growth|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|response to peptide|
|carbohydrate metabolic process|
|regulation of anatomical structure size|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|cellular response to nitrogen compound|
|protein ubiquitination|
|cellular chemical homeostasis|
|protein modification by small protein conjugation|
|negative regulation of catalytic activity|
|negative regulation of transcription by RNA polymerase II|
|cellular homeostasis|
|response to hormone|
|embryo development|
|protein modification by small protein conjugation or removal|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|homeostatic process|
|negative regulation of gene expression|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.91|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.73|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14355
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDTC1 Expression in NALM6 Cells: 3.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>