WDTC1

Entrez Summary: N/A
UniProt Summary: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16964240}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of fatty acid biosynthetic process
negative regulation of fatty acid metabolic process
enzyme inhibitor activity
regulation of fatty acid biosynthetic process
negative regulation of lipid biosynthetic process
multicellular organism growth
negative regulation of lipid metabolic process
regulation of fatty acid metabolic process
negative regulation of small molecule metabolic process
histone deacetylase binding
glucose metabolic process
histone binding
hexose metabolic process
cellular response to insulin stimulus
regulation of cellular ketone metabolic process
regulation of cell size
regulation of lipid biosynthetic process
monosaccharide metabolic process
response to insulin
cellular response to peptide hormone stimulus
cellular response to peptide
post-translational protein modification
in utero embryonic development
regulation of cellular component size
developmental growth
response to peptide hormone
growth
regulation of lipid metabolic process
regulation of small molecule metabolic process
response to peptide
carbohydrate metabolic process
regulation of anatomical structure size
cellular response to organonitrogen compound
cellular response to hormone stimulus
chordate embryonic development
embryo development ending in birth or egg hatching
cellular response to nitrogen compound
protein ubiquitination
cellular chemical homeostasis
protein modification by small protein conjugation