WDYHV1

Gene Information
  • Official Symbol: WDYHV1
  • Official Name: WDYHV motif containing 1
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 55093
  • UniProt: Q96HA8
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: N/A
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. {ECO:0000250|UniProtKB:Q80WB5}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 11708
  • Expression level (log2 read counts): 3.5

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1