WEE2

Entrez Summary: N/A
UniProt Summary: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase Tyr
Pkinase

female pronucleus assembly
negative regulation of oocyte maturation
negative regulation of oocyte development
negative regulation of oogenesis
regulation of oocyte maturation
regulation of meiosis I
negative regulation of cell maturation
regulation of oocyte development
regulation of oogenesis
regulation of cell maturation
regulation of fertilization
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cyclin-dependent protein kinase activity
female meiotic nuclear division
regulation of meiotic nuclear division
non-membrane spanning protein tyrosine kinase activity
regulation of meiotic cell cycle
negative regulation of reproductive process
protein tyrosine kinase activity
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
female gamete generation
negative regulation of protein serine/threonine kinase activity
nucleus organization
single fertilization
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
meiotic nuclear division
mitotic cell cycle checkpoint
regulation of reproductive process
meiotic cell cycle process
fertilization
regulation of nuclear division
cell cycle checkpoint
negative regulation of multi-organism process
magnesium ion binding
meiotic cell cycle
negative regulation of protein kinase activity
protein kinase activity
negative regulation of kinase activity