WFIKKN2

Gene Information

Official Symbol: WFIKKN2
Official Name: WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
Aliases and Previous Symbols: N/A
Entrez ID: 124857
UniProt: Q8TEU8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7844
Expression level (log2 read counts): -3.28

Expression Distribution

I-set
Kazal 2
Kunitz BPTI
NTR
WAP

metalloendopeptidase inhibitor activity
transforming growth factor beta binding
receptor antagonist activity
negative regulation of DNA binding
negative regulation of signaling receptor activity
muscle fiber development
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
roof of mouth development
serine-type endopeptidase inhibitor activity
transforming growth factor beta receptor signaling pathway
negative regulation of protein binding
regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
regulation of DNA binding
striated muscle cell development
negative regulation of cellular response to growth factor stimulus
muscle cell development
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
negative regulation of binding
regulation of signaling receptor activity
transmembrane receptor protein serine/threonine kinase signaling pathway
striated muscle cell differentiation
regulation of protein binding
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of endopeptidase activity
muscle cell differentiation
negative regulation of peptidase activity
regulation of cellular response to growth factor stimulus
negative regulation of proteolysis
regulation of binding
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
muscle structure development
skeletal system development
cellular response to growth factor stimulus
response to growth factor