WIPI1

Entrez Summary: N/A
UniProt Summary: Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation- induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. {ECO:0000269|PubMed:15020712, ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20114074, ECO:0000269|PubMed:20484055, ECO:0000269|PubMed:20639694, ECO:0000269|PubMed:21317285, ECO:0000269|PubMed:22829830, ECO:0000269|PubMed:23088497}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Fas-L 44ng/ml R08 exp482	1.71
iCRT14 30μM R08 exp492	1.85

vesicle targeting, trans-Golgi to endosome
protein localization to phagophore assembly site
phagophore assembly site membrane
Golgi to endosome transport
phagophore assembly site
phosphatidylinositol-3,5-bisphosphate binding
autophagosome membrane
mitochondrion disassembly
autophagy of mitochondrion
phosphatidylinositol-3-phosphate binding
estrogen receptor binding
androgen receptor binding
IRE1-mediated unfolded protein response
clathrin-coated vesicle
autophagosome assembly
organelle disassembly
autophagosome organization
extrinsic component of membrane
vesicle targeting, to, from or within Golgi
protein lipidation
vesicle targeting
lipoprotein biosynthetic process
post-Golgi vesicle-mediated transport
endoplasmic reticulum unfolded protein response
lipoprotein metabolic process
cellular response to unfolded protein
vacuole organization
cytosolic transport
cellular response to topologically incorrect protein
cellular response to starvation
macroautophagy
response to unfolded protein
trans-Golgi network
establishment of vesicle localization
vesicle localization
response to topologically incorrect protein
response to starvation
endosome membrane
cellular response to nutrient levels
response to endoplasmic reticulum stress