WISP2

Entrez Summary: N/A
UniProt Summary: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Geldanamycin 0.01μM R05 exp235	1.86
Cabazitaxel 0.001μM R05 exp223	1.87
DABN 2μM R00 exp16	1.95
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.35

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

insulin-like growth factor binding
integrin binding
heparin binding
extracellular matrix
cell adhesion
biological adhesion
negative regulation of cell death
cell-cell signaling
extracellular space
regulation of cell death