WIZ

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Betulinic acid 10 to 15μM on day4 R05 exp222	-1.88
Mdivi-1 15μM R05 exp217	1.85

SET domain binding
positive regulation of nuclear cell cycle DNA replication
positive regulation of DNA-dependent DNA replication
protein heterotrimerization
regulation of nuclear cell cycle DNA replication
positive regulation of DNA replication
protein trimerization
regulation of DNA-dependent DNA replication
protein heterooligomerization
regulation of DNA replication
midbody
protein stabilization
nucleic acid binding
positive regulation of cell cycle process
regulation of protein stability
positive regulation of cell cycle
protein complex oligomerization
DNA-binding transcription factor activity
regulation of cell cycle process
regulation of cell cycle
protein-containing complex assembly
DNA-binding transcription factor activity, RNA polymerase II-specific
protein-containing complex subunit organization
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of biosynthetic process