WNT8B

Entrez Summary: N/A
UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. {ECO:0000269|PubMed:9536085}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

determination of dorsal identity
determination of dorsal/ventral asymmetry
beta-catenin destruction complex disassembly
receptor ligand activity
frizzled binding
cellular response to retinoic acid
dorsal/ventral pattern formation
canonical Wnt signaling pathway
response to retinoic acid
determination of bilateral symmetry
specification of symmetry
response to estradiol
gastrulation
cellular response to acid chemical
protein-containing complex disassembly
cell fate commitment
regionalization
response to acid chemical
Wnt signaling pathway
cell-cell signaling by wnt
cellular component disassembly
cell surface receptor signaling pathway involved in cell-cell signaling
pattern specification process
cellular response to lipid
embryonic morphogenesis
response to lipid
response to hormone
response to organic cyclic compound
embryo development
neuron differentiation
cellular response to oxygen-containing compound
cell-cell signaling
response to endogenous stimulus
generation of neurons
response to oxygen-containing compound
extracellular space
neurogenesis
protein-containing complex subunit organization
extracellular region