WNT9A

Entrez Summary: N/A
UniProt Summary: Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta- catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity. {ECO:0000250|UniProtKB:O42280, ECO:0000250|UniProtKB:Q8R5M2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cornea development in camera-type eye
iris morphogenesis
embryonic skeletal joint development
negative regulation of chondrocyte differentiation
negative regulation of cartilage development
positive regulation of smoothened signaling pathway
receptor ligand activity
embryonic forelimb morphogenesis
frizzled binding
forelimb morphogenesis
regulation of chondrocyte differentiation
cellular response to retinoic acid
regulation of cartilage development
regulation of smoothened signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
canonical Wnt signaling pathway
negative regulation of cysteine-type endopeptidase activity
embryonic skeletal system morphogenesis
response to retinoic acid
camera-type eye morphogenesis
embryonic limb morphogenesis
embryonic appendage morphogenesis
embryonic skeletal system development
eye morphogenesis
limb morphogenesis
appendage morphogenesis
mitotic cell cycle checkpoint
appendage development
limb development
cell cycle checkpoint
cellular response to acid chemical
regulation of cysteine-type endopeptidase activity involved in apoptotic process
skeletal system morphogenesis
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
cell fate commitment
negative regulation of peptidase activity
sensory organ morphogenesis
embryonic organ morphogenesis
negative regulation of mitotic cell cycle