YOD1

Gene Information

Official Symbol: YOD1
Official Name: YOD1 deubiquitinase
Aliases and Previous Symbols: N/A
Entrez ID: 55432
UniProt: Q5VVQ6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622). {ECO:0000269|PubMed:19818707, ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:27753622}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14289
Expression level (log2 read counts): -3.7

Expression Distribution

protein K27-linked deubiquitination
protein K33-linked deubiquitination
protein K29-linked deubiquitination
ubiquitinyl hydrolase activity
negative regulation of retrograde protein transport, ER to cytosol
negative regulation of protein exit from endoplasmic reticulum
protein K11-linked deubiquitination
Lys63-specific deubiquitinase activity
regulation of retrograde protein transport, ER to cytosol
negative regulation of ERAD pathway
Lys48-specific deubiquitinase activity
regulation of protein exit from endoplasmic reticulum
regulation of ERAD pathway
protein K63-linked deubiquitination
protein K48-linked deubiquitination
negative regulation of intracellular protein transport
negative regulation of response to endoplasmic reticulum stress
negative regulation of proteasomal protein catabolic process
negative regulation of intracellular transport
ubiquitin-dependent ERAD pathway
negative regulation of proteolysis involved in cellular protein catabolic process
regulation of response to endoplasmic reticulum stress
negative regulation of cellular protein catabolic process
ERAD pathway
endoplasmic reticulum unfolded protein response
thiol-dependent ubiquitin-specific protease activity
negative regulation of cellular protein localization
cellular response to unfolded protein
negative regulation of protein catabolic process
cellular response to topologically incorrect protein
macroautophagy
response to unfolded protein
negative regulation of protein transport
regulation of proteasomal protein catabolic process
negative regulation of establishment of protein localization
response to topologically incorrect protein
nucleic acid binding
regulation of proteolysis involved in cellular protein catabolic process
regulation of intracellular protein transport
regulation of cellular protein catabolic process