YWHAB

Gene Information

Official Symbol: YWHAB
Official Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Aliases and Previous Symbols: N/A
Entrez ID: 7529
UniProt: P31946
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21224381}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9815
Expression level (log2 read counts): 8.02

Expression Distribution

Screen	Score
Cytochalasin-B 5μM R07 exp349	-1.73
BI-6727 0.0125μM R03 exp97	1.88

phosphoserine residue binding
cytoplasmic sequestering of protein
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
vacuolar membrane
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
hippo signaling
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
phosphoprotein binding
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
negative regulation of G protein-coupled receptor signaling pathway
transcriptional repressor complex
positive regulation of establishment of protein localization to mitochondrion
negative regulation of protein dephosphorylation
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
regulation of membrane permeability
melanosome
maintenance of protein location
protein heterooligomerization
negative regulation of dephosphorylation
histone deacetylase binding
positive regulation of mitochondrion organization
positive regulation of protein localization to membrane
mitochondrial membrane organization
regulation of protein dephosphorylation
regulation of G protein-coupled receptor signaling pathway
maintenance of location
positive regulation of apoptotic signaling pathway
regulation of mRNA stability
regulation of mitochondrion organization
regulation of RNA stability
regulation of protein localization to membrane
protein C-terminus binding
regulation of mRNA catabolic process
regulation of dephosphorylation
mitochondrial transport
protein domain specific binding
protein-containing complex binding
cadherin binding
positive regulation of cellular protein localization