ZBED1
Gene Information
- Official Symbol: ZBED1
- Official Name: zinc finger BED-type containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9189
- UniProt: O96006
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010].
- UniProt Summary: Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 promoter and stimulates transcription. Was first identified as gene weakly similar to Ac transposable elements, but does not code for any transposase activity. {ECO:0000269|PubMed:12663651}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3831
- Expression level (log2 read counts): 5.79
ZBED1 Expression in NALM6 Cells: 5.79
