ZC3H10

Entrez Summary: N/A
UniProt Summary: Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA. {ECO:0000269|PubMed:28431233}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rifampicin 30μM R08 exp430	1.7
GSK626616 14μM R08 exp485	1.72

negative regulation of production of miRNAs involved in gene silencing by miRNA
negative regulation of gene silencing by miRNA
negative regulation of posttranscriptional gene silencing
negative regulation of gene silencing by RNA
regulation of production of miRNAs involved in gene silencing by miRNA
regulation of production of small RNA involved in gene silencing by RNA
miRNA binding
negative regulation of gene silencing
regulation of alternative mRNA splicing, via spliceosome
regulation of gene silencing by miRNA
regulation of gene silencing by RNA
regulation of posttranscriptional gene silencing
regulation of mRNA splicing, via spliceosome
regulation of gene silencing
regulation of RNA splicing
regulation of mRNA processing
regulation of mRNA metabolic process
posttranscriptional regulation of gene expression
negative regulation of RNA metabolic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
negative regulation of gene expression
positive regulation of gene expression