ZFP42

Entrez Summary: N/A
UniProt Summary: Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PcG protein complex
female gonad development
development of primary female sexual characteristics
RNA polymerase II distal enhancer sequence-specific DNA binding
female sex differentiation
male gonad development
development of primary male sexual characteristics
male sex differentiation
transcription factor complex
gonad development
development of primary sexual characteristics
meiotic cell cycle
nuclear chromatin
sex differentiation
sequence-specific DNA binding
reproductive structure development
reproductive system development
RNA polymerase II proximal promoter sequence-specific DNA binding
developmental process involved in reproduction
DNA-binding transcription factor activity
cell cycle
reproductive process
reproduction
DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific