ZMYND8 [The Human Chemical-Genetic Interaction Map Project]

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======= ZMYND8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZMYND8
  * **<color #00a2e8>Official Name</color>**: zinc finger MYND-type containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23613|23613]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULU4|Q9ULU4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZMYND8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZMYND8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615713|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Bromodomain|
|PHD|
|PWWP|
|DUF3544|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of postsynaptic density protein 95 clustering|
|positive regulation of dendritic spine maintenance|
|regulation of dendritic spine maintenance|
|regulation of postsynaptic membrane organization|
|regulation of postsynaptic density organization|
|lysine-acetylated histone binding|
|positive regulation of filopodium assembly|
|dendritic shaft|
|repressing transcription factor binding|
|modulation of excitatory postsynaptic potential|
|positive regulation of dendritic spine development|
|regulation of filopodium assembly|
|methylated histone binding|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|regulation of postsynapse organization|
|positive regulation of plasma membrane bounded cell projection assembly|
|protein N-terminus binding|
|regulation of nervous system process|
|dendritic spine|
|regulation of dendrite development|
|regulation of protein localization to membrane|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|transcription corepressor activity|
|protein domain specific binding|
|negative regulation of cell migration|
|negative regulation of cell motility|
|positive regulation of neuron projection development|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of membrane potential|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|positive regulation of cellular component biogenesis|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|regulation of system process|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|zinc ion binding|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of protein localization|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.7|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.72|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.83|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.9|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.91|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.92|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.92|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|1.94|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.08|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.1|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.13|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.21|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.32|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.8|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.96|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:znf592|ZNF592]]|0.475|
|[[:human genes:b:brpf1|BRPF1]]|0.452|
|[[:human genes:m:max|MAX]]|0.433|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 56/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|8/28|
|bone|2/25|
|breast|3/33|
|central nervous system|5/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|0/21|
|liver|0/20|
|lung|3/75|
|lymphocyte|2/14|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|1/7|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1081
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZMYND8 Expression in NALM6 Cells: 6.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>