ZMYND8

Gene Information

Official Symbol: ZMYND8
Official Name: zinc finger MYND-type containing 8
Aliases and Previous Symbols: N/A
Entrez ID: 23613
UniProt: Q9ULU4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Actinomycin-D 0.001μM R00 exp3	1.7
MLN-4924 0.2μM R00 exp21	1.72
Staurosporine 0.02μM R08 exp524	1.83
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	1.9
Rotenone 20μM R00 exp34	1.91
Diepoxybutane 3μM R07 exp354	1.92
RO-3307 4.7μM R02 exp80	1.92
Epigallocatechin gallate 20μM R05 exp230	1.94
CoCl2 18μM R07 exp346	2.08
Mdivi-1 15μM R05 exp217	2.1
Pterostilbene 16μM R02 exp78	2.13
UMK57 1μM R01 exp59	2.21
BML-284 0.09μM R08 exp460	2.32
Aphidicolin 0.4μM R08 exp440	2.8
5-Fluorouracil 20μM R00 exp2	2.96
UM131593 0.2μM R03 exp106	2.96

Global Fraction of Cell Lines Where Essential: 56/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	8/28
bone	2/25
breast	3/33
central nervous system	5/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/15
kidney	0/21
liver	0/20
lung	3/75
lymphocyte	2/14
ovary	0/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	9/15
prostate	0/1
skin	5/24
soft tissue	1/7
thyroid	1/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1081
Expression level (log2 read counts): 6.51

Expression Distribution

Gene	Correlation
ZNF592	0.475
BRPF1	0.452
MAX	0.433

Bromodomain
PHD
PWWP
DUF3544

regulation of postsynaptic density protein 95 clustering
positive regulation of dendritic spine maintenance
regulation of dendritic spine maintenance
regulation of postsynaptic membrane organization
regulation of postsynaptic density organization
lysine-acetylated histone binding
positive regulation of filopodium assembly
dendritic shaft
repressing transcription factor binding
modulation of excitatory postsynaptic potential
positive regulation of dendritic spine development
regulation of filopodium assembly
methylated histone binding
positive regulation of dendrite development
regulation of dendritic spine development
regulation of postsynapse organization
positive regulation of plasma membrane bounded cell projection assembly
protein N-terminus binding
regulation of nervous system process
dendritic spine
regulation of dendrite development
regulation of protein localization to membrane
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of synapse organization
regulation of synapse structure or activity
transcription corepressor activity
protein domain specific binding
negative regulation of cell migration
negative regulation of cell motility
positive regulation of neuron projection development
negative regulation of cellular component movement
negative regulation of locomotion
positive regulation of neuron differentiation
positive regulation of cell projection organization
regulation of membrane potential
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
positive regulation of neurogenesis
regulation of neuron projection development