ZNF175

Gene Information

Official Symbol: ZNF175
Official Name: zinc finger protein 175
Aliases and Previous Symbols: N/A
Entrez ID: 7728
UniProt: Q9Y473
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat- induced viral LTR promoter activity. {ECO:0000269|PubMed:14688346}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17142
Expression level (log2 read counts): 4.73

Expression Distribution

zf-C2H2
KRAB

intermediate filament cytoskeleton
defense response to virus
DNA-binding transcription repressor activity, RNA polymerase II-specific
response to virus
RNA polymerase II regulatory region sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
defense response to other organism
immune effector process
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
response to other organism
response to external biotic stimulus
response to biotic stimulus
negative regulation of RNA metabolic process
defense response
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process