ZNF207 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF207 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF207
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 207
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7756|7756]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43670|O43670]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF207&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF207|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603428|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187, ECO:0000269|PubMed:26388440}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spindle matrix|
|attachment of spindle microtubules to kinetochore|
|mitotic spindle assembly checkpoint|
|spindle checkpoint|
|mitotic spindle checkpoint|
|spindle assembly checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|negative regulation of mitotic sister chromatid segregation|
|microtubule polymerization|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|mitotic spindle assembly|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|microtubule polymerization or depolymerization|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|mitotic spindle organization|
|regulation of sister chromatid segregation|
|kinetochore|
|protein polymerization|
|condensed chromosome kinetochore|
|microtubule bundle formation|
|spindle assembly|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|spindle|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|mitotic nuclear division|
|mitotic cell cycle checkpoint|
|spindle organization|
|regulation of mitotic nuclear division|
|heparin binding|
|protein stabilization|
|regulation of nuclear division|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|nuclear chromosome segregation|
|negative regulation of cell cycle phase transition|
|microtubule binding|
|chromosome segregation|
|nuclear division|
|regulation of protein stability|
|negative regulation of mitotic cell cycle|
|organelle fission|
|microtubule|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|negative regulation of organelle organization|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|cell division|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|organelle assembly|
|zinc ion binding|
|cellular protein-containing complex assembly|
|nucleolus|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|RNA binding|
|DNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.7|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|1.73|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.77|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.84|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.87|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|2.02|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.03|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.16|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.17|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.19|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.23|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.24|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.26|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.38|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.42|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.63|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|3.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 339/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|19/28|
|bone|9/26|
|breast|17/33|
|central nervous system|22/56|
|cervix|1/4|
|colorectal|8/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|15/21|
|liver|6/20|
|lung|35/75|
|lymphocyte|6/16|
|ovary|13/26|
|pancreas|6/24|
|peripheral nervous system|11/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|17/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1741
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF207 Expression in NALM6 Cells: 8.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>