ZNF268

Gene Information

Official Symbol: ZNF268
Official Name: zinc finger protein 268
Aliases and Previous Symbols: N/A
Entrez ID: 10795
UniProt: Q14587
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6726
Expression level (log2 read counts): 6.15

Expression Distribution

zf-C2H2
KRAB

negative regulation of cell cycle arrest
regulation of cell cycle arrest
actin cytoskeleton
negative regulation of cell cycle process
positive regulation of cell cycle
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
negative regulation of cell cycle
regulation of mitotic cell cycle
positive regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of cell population proliferation
DNA-binding transcription factor activity
positive regulation of cell death
regulation of cell cycle process
regulation of cell migration
negative regulation of transcription by RNA polymerase II
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of cell motility
positive regulation of cell population proliferation
positive regulation of cell differentiation
regulation of locomotion
negative regulation of cell death
regulation of cellular component movement
regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
positive regulation of developmental process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated