ZNF330 [The Human Chemical-Genetic Interaction Map Project]

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======= ZNF330 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF330
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 330
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27309|27309]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3S2|Q9Y3S2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF330&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF330|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609550|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NOA36|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromosome, centromeric region|
|midbody|
|zinc ion binding|
|nucleolus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-2|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.93|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.93|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.86|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.73|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.72|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.84|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.97|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.09|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.09|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.39|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.54|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.71|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.83|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slfn11|SLFN11]]|0.469|
|[[:human genes:r:rwdd4|RWDD4]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17410
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF330 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>