ZNF593

Entrez Summary: N/A
UniProt Summary: Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
ribosomal large subunit export from nucleus
ribosomal subunit export from nucleus
ribosome localization
ribosomal large subunit binding
regulation of RNA polymerase II regulatory region sequence-specific DNA binding
rRNA-containing ribonucleoprotein complex export from nucleus
negative regulation of transcription regulatory region DNA binding
preribosome, large subunit precursor
regulation of transcription regulatory region DNA binding
negative regulation of DNA binding
ribonucleoprotein complex export from nucleus
regulation of DNA binding
ribonucleoprotein complex localization
RNA export from nucleus
protein export from nucleus
nuclear export
negative regulation of binding
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
ribosome biogenesis
establishment of organelle localization
regulation of binding
ribonucleoprotein complex biogenesis
organelle localization
zinc ion binding
nucleolus
intracellular protein transport
negative regulation of molecular function
positive regulation of transcription by RNA polymerase II
DNA binding
protein transport
intracellular transport
peptide transport