ZNF609

Entrez Summary: N/A
UniProt Summary: Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others. {ECO:0000250|UniProtKB:Q8BZ47}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of myoblast proliferation
positive regulation of neuron migration
integrator complex
regulation of neuron migration
nucleic acid binding
muscle organ development
positive regulation of neurogenesis
muscle structure development
positive regulation of cell migration
positive regulation of cell motility
positive regulation of nervous system development
positive regulation of cellular component movement
positive regulation of cell development
positive regulation of locomotion
regulation of neurogenesis
regulation of cell migration
regulation of cell motility
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
regulation of locomotion
regulation of cellular component movement
positive regulation of transcription by RNA polymerase II
positive regulation of developmental process
generation of neurons
positive regulation of transcription, DNA-templated
regulation of cell population proliferation
neurogenesis
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of multicellular organismal process
regulation of cell differentiation
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process